About RIFAMPICIN+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE
ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow.
ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN is a combination of four drugs: Isoniazid, Pyrazinamide, Pyridoxine hydrochloride (vitamin B6), and Rifampicin. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the bacterial cell wall. Pyrazinamide is an antibiotic that works by stopping the growth of bacteria that cause tuberculosis. Pyridoxine hydrochloride treats nerve damage (neuritis) caused by tuberculosis. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria.
Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN include muscle/joint pain, nausea, vomiting, rash, dark-coloured urine, weakness, dry mouth, stomach pain, and upset stomach. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
Avoid foods and drinks that contain histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as they may interact. Maintain a gap of one hour between ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN and antacid medicines. ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN may cause dizziness, and vision problems, so drive with caution. Let your doctor know if you are pregnant, planning to conceive, or are a breastfeeding mother. Avoid consuming alcohol with ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as it might lead to liver problems. ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN should be used in children only when the doctor has prescribed it.
Uses of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE
Tuberculosis (TB).
Medicinal Benefits
ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN contains Isoniazid, Pyrazinamide, Pyridoxine hydrochloride (vitamin B6), and Rifampicin. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the bacterial cell wall. Pyrazinamide is an antibiotic that works by stopping the growth of bacteria that cause tuberculosis. Pyridoxine hydrochloride (vitamin B6) treats nerve damage (neuritis) caused by tuberculosis. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Together, ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Directions for Use
Storage
Side Effects of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE
- Muscle/joint pain
- Nausea
- Vomiting
- Rash
- Dark coloured urine
- Weakness
- Dry mouth
- Stomach pain
- Upset stomach
In-Depth Precautions and Warning
Drug Warnings
Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as they might cause interaction. Maintain a gap of one hour between ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN and antacid medicines. Consult your doctor before taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN if you are pregnant. Breastfeeding mothers should speak to a doctor before they take ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN since it passes into breast milk. ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN may cause dizziness, and vision problems, so drive with caution. Avoid alcohol consumption while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as it could lead to increased liver damage. Store ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN below 25°C away from direct sunlight.
Drug Interactions
Drug-Drug Interaction: ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN may interact with antibiotics (erythromycin), pain killers (acetaminophen), anti-diabetic drugs (insulin isophane), anti-HIV drugs (saquinavir, ritonavir), supplements (ergocalciferol), gout medicines (probenecid, sulfinpyrazone), and oral contraceptives.
Drug-Food Interaction: Do not consume alcohol while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN as they might cause interaction.
Drug-Disease Interaction: ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN may interact with colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, hemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney, and liver dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption while taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN. Alcohol intake, along with ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN, may cause increased liver damage. Please consult your doctor for more information.
Pregnancy
cautionPlease consult your doctor if you are pregnant, or planning a pregnancy; your doctor will prescribe ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN only if the benefits outweigh the risks.
Breast Feeding
unsafeISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm your baby. However, please consult your doctor before taking ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN if you are a breastfeeding mother.
Driving
unsafeISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Liver
cautionPlease consult your doctor since ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN should be used with caution in patients with liver impairment/liver disease. Regular monitoring of liver function tests is also advised.
Kidney
cautionPlease consult your doctor since ISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.
Children
safe if prescribedISONIAZID+PYRAZINAMIDE+PYRIDOXINE HYDROCHLORIDE+RIFAMPICIN is recommended in children only when the doctor has prescribed it.
Habit Forming
Diet & Lifestyle Advise
- Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
- Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system.
- Avoid processed and fried foods.
- Warm ginger tea or warm soup can help in providing relief from a cough.
- Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
- Quit smoking and avoid alcohol consumption.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.
